Olimpia’s Juan Manuel Salgueiro and Santa Fe’s Gerardo Bedoya were both sent off on the stroke of half time to reduce the teams to 10 men.
Herminio Miranda and substitute Juan Carlos Ferreyra struck the crucial goals which gives three time winners Olimpia a crucial first leg advantage.
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Liverpool have unveiled their new home kit for next season, sticking with the hugely popular retro styling of the current shirt.
The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.