Blas Perez and Roman Torres netted the goals for Panama, who now face the United States in the final after a result which will heap pressure on Jose Manuel de la Torre as Mexico coach.
The US reached the final with a comfortable 3-1 win over Honduras.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.