The duo have not played together since August, with Pique recently returning from a foot injury.
Puyol suffered a dislocated elbow at the start of the season, and it would be a brave move by Tito Vilanova to bring the pair back so soon to shore up what has been a leaky defence.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.