Vilanova is missing a first choice defence with Carles Puyol, Eric Abidal and Dani Alves all injured.
“The missing players aren’t an excuse for everything,” Vilanova told a news conference.
“At the end of the day, all the players are Barca players and capable of playing to the highest standard.”
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.