Armenia are one of the most improved teams in Europe and Italy are looking for all three points, but Prandelli warned it will not be easy.
“They are a team evolving,” he said. “They are a modern team who are great going forward. We have watched a video of their last three or four games, and we need to watch out for their attackers.
“We must respect the opposition, and play with the intensity the game deserves.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.