The Dutchman was forced off with a hip injury in United’s 2-0 win over QPR at the weekend.
United are assessing his fitness, but the prolific forward only has just over a week to recover in time for the home tie with Madrid, with the score at 1-1 after the first leg.
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Chelsea have struggled to build momentum in the opening stages of the campaign and are currently looking over their shoulders at the relegation zone.
Who of Europe’s top strikers will move to England this summer?