The Dutchman was forced off with a hip injury in United’s 2-0 win over QPR at the weekend.
United are assessing his fitness, but the prolific forward only has just over a week to recover in time for the home tie with Madrid, with the score at 1-1 after the first leg.
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Who of Europe’s top strikers will move to England this summer?
After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.