The Dutchman was forced off with a hip injury in United’s 2-0 win over QPR at the weekend.
United are assessing his fitness, but the prolific forward only has just over a week to recover in time for the home tie with Madrid, with the score at 1-1 after the first leg.
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Summer 2016 is set to be a very exciting time for football fans, as this is when the long awaited Euro 2016 tournament kicks off.
Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.