The draw came days after Real had won 5-0 at the same stadium against the same team.
They win 3-1 on aggregate, although Fabio Contreao and Angel di Maria were both sent off.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.