Piotr Trochowski scored the only goal of the game as Sevilla beat the champions at home.
Barcelona’s 4-1 win at Getafe now means that they are already eight points clear of their title rivals after four matches.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.