The 24-year-old has partially torn his ankle ligament and the injury will see him miss Germany’s World Cup qualifiers against Ireland and Sweden.
Reus has impressed so far this season, scoring seven goals in 13 appearances for Borussia Dortmund.
The injury could see Reus miss the Champions League clash with Arsenal later this month.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.