Last year’s runners up won 1-0 away at Nacional despite playing with 10 men for long periods.
Riquelme’s winning goal from the spot was his first since returning to his boyhood club after retiring last season.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.