Bayern have won all eight of their league matches this season and host Bayer Leverkusen hoping to extend their remarkable run.
One player who looks unlikely to make it though is Frenchman Franck Ribery.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.