The Brazilian sustained the injury during the defeat to Sampdoria.
It is another blow for Milan, who have undergone a summer of upheaval and are light on options up front.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.