Santa Cruz spent last season on loan with the Seville outfit.
He is one of the players Man City want off their payroll, and the Daily Mirror report that he is ready to tear up his contract to secure a return to Spain.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.