Mainz stunned the Ruhr outfit with a 2-1 win away from home, adding to Schalke’s misery.
The club have recently fired Huub Stevens and replaced him with Jens Keller, despite their impressive showings in the Champions League.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.