The 33-year-old is struggling with a recurring Achilles tendon injury.
Karhan will be out of action for three weeks.
“There’s a little tear which means I can’t take part in the tournament,” said Karhan.
“I have a three-week break ahead of me and the World Cup begins in two weeks. So my withdrawal is final.”
What is your opinion? Feel free to discuss the article under. You have to comment by using your Facebook profile. Be fair and have respect for other people and opinions!
Who of Europe’s top strikers will move to England this summer?
After a dreadful start to their Bundesliga campaign, Borussia Dortmund appear to have weathered the storm after going five matches without defeat.