Goals from Alvaro Morata, Isco and Alvaro Vasquez secured what was an easy win in the end against a much changed Dutch team.
Germany beat Russia in the last group game, an irrelevant match in terms of qualification with both teams already out.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.