The stocky Chilean is absent after suffering an injury in training at the end of last week.
He has returned to Mexico, meaning more pressure will be on Neri Cardozo and Cesar Delgado going forward for Monterrey.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.