The Arsenal goalkeeper is missing with an ankle injury, meaning Vito Mannone will deputise.
Szczesny made an error in the weekend match against Southampton, letting in the first goal Arsenal have conceded this season.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.