The 25-year-old has signed a four-year contract with the Premier League side.
Reports claim Spurs have agreed a deal believed to be worth up to £12million for the highly-rated keeper.
A statement on Lyon’s website read: “Olympique Lyonnais would like to thank the man for his qualities which made him the captain of France and one of the best goalkeepers in the world and his rapport with the whole organisation and the supporters.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.