Chelsea will also face Napoli, whilst Bayern play Basle and Lyon face APOEL.
Barcelona will take on Bayer Leverkusen, Real Madrid face CSKA Moscow, Benfica play Zenit St Petersburg and Inter Milan will have Marseille.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.