United overtook Chelsea, who drew 1-1 with Swansea, to go top for the first time this season.
Manchester City also failed to win, drawing 0-0 with West Ham, while Tottenham were beaten 1-0 by Wigan.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.