Vilanova missed much of last season after being appointed to replace Pep Guardiola because of throat cancer.
“Following routine tests, it was decided that he would follow a course of treatment to continue to control his illness that is incompatible with fulfilling his role as coach of the first team,” club President Sandro Rosell said.
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Liverpool have unveiled their new home kit for next season, sticking with the hugely popular retro styling of the current shirt.
The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.