Club President Sandro Rosell will be travelling to New York, where Vilanova is undergoing treatment for cancer, to determine whether he can return or not for the Milan game.
Barcelona are 2-0 down following the first leg in Italy earlier this month.
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Chelsea have struggled to build momentum in the opening stages of the campaign and are currently looking over their shoulders at the relegation zone.
Who of Europe’s top strikers will move to England this summer?