Club President Sandro Rosell will be travelling to New York, where Vilanova is undergoing treatment for cancer, to determine whether he can return or not for the Milan game.
Barcelona are 2-0 down following the first leg in Italy earlier this month.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.