The Spanish defender has been out with a foot problem but Barcelona still hope he can be involved, particularly with Carles Puyol injured.
“Pique has been out of action for quite a few days,” Vilanova told a news conference.
“If he had at least trained in this time we would have more information and I am not in favour of (painkilling) injections because this could give us problems further down the line.
“There is no doubt about Pique’s willingness to play because he has dedicated all the hours possible to recover but we cannot fight against nature!”
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The start of the 2017-18 Premier League season is just around the corner and is shaping up to be one of the most competitive yet.
As always it is the so called “big clubs” that have splashed the most cash in the transfer window so far this summer. Manchester United or City? Arsenal or Tottenham? Who are the winners and losers of the transfer window so far?