The Spaniard has only recently returned from a broken leg but now has an ankle complaint.
“Villa had problems in Moscow (against Spartak), his ankle didn’t like the artificial pitch but it is nothing serious,” Barca coach Tito Vilanova said. “We preferred him to rest.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.