The Mexico international suffered the thigh injury during the 1-0 win over Elche on Monday.
Tests have shown that the former Tottenham ace has suffered a grade one thigh strain, Villarreal have now confirmed.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.