Walcott sustained a slight pelvic tear on Friday and was sent home from international duty to return to his club.
The injury could keep him out for 10 days, meaning he may not return until April.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.