The two sides meet at the Etihad Stadium with the visitors hoping to continue their good away form.
“We are confident that against the best teams in the league we can do well,” added Vertonghen. “Maybe it is because we have a lot of pace and we can hurt them in transition … I think we played our best games in the away games so that gives us confidence.”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.