The two sides meet at the Etihad Stadium with the visitors hoping to continue their good away form.
“We are confident that against the best teams in the league we can do well,” added Vertonghen. “Maybe it is because we have a lot of pace and we can hurt them in transition … I think we played our best games in the away games so that gives us confidence.”
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.