Xavi has missed the two recent Clasicos with Real Madrid because of a hamstring strain, and his absence was sorely felt as they lost both times.
His return would be a major boost with Milan leading 2-0 from the first leg of their Champions League tie.
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.