Xavi has missed the two recent Clasicos with Real Madrid because of a hamstring strain, and his absence was sorely felt as they lost both times.
His return would be a major boost with Milan leading 2-0 from the first leg of their Champions League tie.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.