The 26-year-old has signed a five-year contract with the Russian giants.
The Russian side confirmed their swoop for the forward on their official website on Monday evening.
Hulk has long been linked with a move to Chelsea.
Reports claim Zenit have paid around £40million for the former Tokyo Verdy superstar.
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Since Guus Hiddink arrived at the helm, Chelsea have improved considerably after a tricky start to the campaign.
Newcastle United are staring down the barrel of relegation to the Championship for the second time in the past eight years.