Malouda picked up an ankle injury in the win over Blackburn last weekend.
Frank Lampard, Jose Bosingwa and Yossi Benayoun will also miss the game.
“Malouda has an ankle problem,” confirmed Ancelotti. “He twisted it in the last game and had a scan yesterday. He will have another one today but we don’t think it’s a big problem.
“It was a little twist. I hope he will be ready for the game at Liverpool.
“Lampard and Benayoun will be out, and Bosingwa has not felt well and did not train, so he’s not available.
“We have a lot of games coming up and I don’t want to take a risk. We have important games against Liverpool and Fulham and we want to play them with the players in good condition.”
