But Walter Samuel has given Jose Mourinho a boost after being declared fit enough to travel with the squad to Manchester.
Marco Materazzi and Nicolas Burdisso have already been ruled out of the clash.
Inter Milan president Massimo Moratti admits the injuries is a major blow for the club.
Moratti told reporters: “Yes, it is a pity to have to face this game with many important absentees, players of experience and class that can not be on the pitch.”
