The 17-year-old has been out with an ankle injury and was forced to miss the fourth round victory over Liverpool.
Wilshere said: “I picked up my injury in training but I should be back for the Manchester City game.
“It was frustrating to miss the Liverpool game but it was good to see players come into the side and do well. If people are injured, there are always youngsters who can step up and do a job.
“It will be good to play against Manchester City and I hope they play a full team. We will go there and believe we can win.
“Now we are in the last eight it is realistic for us to think we can win the trophy.
“I think we can beat Manchester City and if we do the competition will be wide open. We can go all the way.”
