Chelsea won the first leg 1-0 at Stamford Bridge and manager Guus Hiddink has a 100 per cent record after taking over from Luiz Felipe Scolari.
Ranieri said in The Sun: “Sooner or later he has to lose and I want it to be here. We are the underdogs, they are the favourites but we will try and do something special.
“Guus is one of the best coaches in Europe and has done a great job wherever he’s been, so it’s not surprising he has fitted in well at Chelsea already.
“The coaching organisation may have changed but the system he plays is roughly the same with two wingers.”
He continued: “It is a huge game not only for Chelsea but ourselves.
“This match will be a duel between a team that is really starting to grow – Chelsea – and a team that is on its way back to the top, Juventus.
“Is this the most important game in my career here? Maybe. But I hope there’ll be more Champions League games this season.”