Vilanova had to leave the post after suffering a relapse in his battle against throat cancer.
Iniesta told AS: “Tito will once again win this terrible battle facing him. On behalf of the players and everyone, I send him all my love and support. At the end of the day, this is about a person, not a coach.”
Meanwhile Messi took to Facebook to issue a simple statement, saying: “Strength Tito! We are all with you in this fight!”
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The reputation of the Premier League means it is the most popular and one of the most watched leagues in the world.
Five English clubs will compete in the last sixteen of the Champions League for the first time ever as Liverpool, Manchester United, Manchester City, Chelsea and Tottenham face some difficult away matches.