The 29-year-old has not started a match since September 2008, but could feature against West Brom.
“Owen should play some part on Saturday,” the player’s knee surgeon Dr Richard Steadman told BBC Sport.
“Our physical therapist, Luke O’Brien, has been working very closely with United’s coaches on his rehab.”
The surgeon conceded: “It’s been a long road back and there have been some setbacks along the way.
“But I’ve got a lot of admiration for the way Owen has responded – he’s worked very hard and has never given up. Things are looking good for him now.”
