The Gunners face the Serbian side in the Champions League on Tuesday night.
Wilshere could be handed a start against Partizan Belgrade after being rested by Wenger against West Brom on Saturday.
“I would not be afraid to play him,” said Wenger.
“It is a possibility he will play. I rested him on Saturday.
“It was just a question of having a breather. He is 18 and has played every single game recently.”
