The Catalans are struggling with injuries and Gerard Pique and Rafael Marquez is suspended following red cards against Getafe last weekend.
“It’s a shame we have so many casualties at the back,” Xavi told Sport.
“We have different options to play in Madrid and, as always, we’re going there to win, to compete and to take all three points.”
“Traditionally it’s a difficult venue for us but we’ll see what happens. Whoever plays will do well, even player’s from the reserve team.”