Boro lost 4-0 to Tottenham on Wednesday and are second from bottom in the Premier League.
“I still always think 40 points is a good guideline,” Southgate told Sky Sports News. “That means we need four wins, we need to go on our travels and pick up at least a win I would say.
“We have got to focus on ourselves there is no point looking at other teams fixtures or concerning ourselves with other teams.
“One or two teams had good results in midweek, but over the course of the week we pulled others a bit closer to us and that will go on indefinitely
“We showed ourselves against Liverpool that we can be competitive in any match, there is a hell of a lot of hard work ahead of us but we are up for that challenge.”