Tevez picked up an knee injury while on international duty with Argentina.
“We heard yesterday (Monday) that Carlos had a knee problem, our doctor has spoken to the Argentine medical people and the feeling is that he is out for the weekend so he will not play against Arsenal,” Hughes told the club’s official website.
“The hope is that he will be OK for the derby, but we will have to determine that when he comes back.
“He is staying with the national squad because he needs acute treatment at the early stage of the injury, which is what he can get now. Flying him back quickly might compromise the injury, so he will be back towards the end of the week so we can assess him and hopefully get him ready for the United game.
“It was an impact injury, he has twisted his knee but it could have happened in a training session or just walking down the road. Its part and parcel of the game, we feel it’s not going to compromise him too much and that it will only be one game that he has to miss.”