Kolo Toure is out due to a suspension, while William Gallas is out due to a thigh problem, for the match against Chelsea at Stamford Bridge on Sunday.
Wenger said: “It will be a challenge but Senderos will play. He’s had some tough games against Drogba. He can show he has improved a lot from last year.
“He had some very good games in the Champions League last season. We didn’t concede for 10 games so I’m very confident he will do well.
“Drogba is playing well but this is part of a learning process. Today, Senderos is more experienced and he can show that against Drogba.
“I’m not worried about the situation. Drogba has got better and Senderos has as well. Who has improved the most? We’ll answer that on Sunday.”