The Republic of Ireland star believes Wolves can beat United due to the Red Devils’ hectic fixture schedule.
The 26-year-old said: “The way the league is going this season, I would not write us off on Saturday.
“United have so many games and, no matter how good a player you are, with that amount of matches it is difficult to do it week in and week out.
“I think that is why you have seen some of the results this season, with the top teams beaten. There have been plenty of surprise results.
“We have less games to play all season, so that is an advantage and hopefully that will show on Saturday.”
Doyle added: “Every game is massive for us now in the fight for survival.
“But we have shown if we play well at home that we can get results against the likes of Tottenham and Liverpool.
“We know the situation we are in and everyone is on their toes and fighting for our Premier League lives.”