Hargreaves is struggling with a troublesome knee injury. The England international has had problems with his knee ever since joining United from Bayern Munich.
Neville will be rested after only recently returning to the starting XI, following 18 months ont he sidelines due to an ankle problem.
Man Utd squad: Van der Sar, Amos, Rafael, Brown, Ferdinand, Vidic, Evans, Evra, O’Shea, Fletcher, Ronaldo, Anderson, Scholes, Park, Giggs, Nani, Gibson, Berbatov, Tevez, Rooney, Welbeck.
