The Magpies are in the bottom three following their 1-0 defeat at home by Fulham.
“The question’s been asked on four or five occasions over the last four or five games of ‘is this the biggest game of your career?'” said Shearer on Sky Sports News.
“I keep answering ‘yes’ because it’s the next one, but we know what’s at stake, we know what’s riding on it.
“I’m pretty confident we can go there and give our great fans something to shout about, I really am.”
He added: “I’m totally convinced we’ll get out of it and I think, more importantly, so are my players.
“I asked them to forget last weekend’s result. I thought we played well and whether we had good decisions or bad decisions, it’s gone, we can’t change that.
“What we can change is this weekend. I believe if we go there and we win, it will be a very, very good day for us.”