Villarreal are struggling with several injuries to striker Nihat Kahveci and Robert Pires ahead of the clash.
Rossi have also struggled with an ankle injury in recent weeks, and must prove his fitness before he can play the match.
“I’m hopeful I can feature,” he told EFE. “I feel good and I’m slowly recovering my best form.
“The game against United will be a great encounter against the best team in the world and for me it’s going to be special having played there.
“All the players at Villarreal can’t wait to play such a game.”